Pre-measuring - Might be my absolute favorite change to the game. No more, I was off by .021421 inches, and therefore my entire plan falls to crap.
Card Format - This is an asthetic change. The cards are now smaller, fitting into the standard card size for most CCG's. Im cool with this change as it means I wont have to go laminate my cards every month when I get a new model. I'll just buy a box of sleeves from my LGS and get to gaming!
Strategy / Schemes - I like them. It seems they took a lot of the best ideas they had over the past several attempts to make the missions and worked out a core few. Balancing 13 missions is really tough. I like that they have a "competative" pack of 5 missions that will more geared towards tournament and the like. Plus I like the feel of these missions. The Schemes are cool in my mind too. I grew to really like the scheme pool. Prevents Body-Guard / Kill Protege every game.